“We are located at the Research Institute for Medicines at the Pharmacy Faculty of the Lisbon University and our research interests span over the interface of organic chemistry and biology.”
Chemistry offers unique possibilities to rationally manipulate biological processes and will most certainly play a major role in unravelling solutions for current unmet medical needs. Broadly our team is focusing on discovering innovative chemical methods that permit the construction of functional molecules, and on applying these technologies to the construction of therapeutic bioconjugates.
In detail, the discovery of new functional boron complexes, methods to functionalize proteins in a reversibly and/or orthogonal manner, and the assembly of stimuli responsive bioconjugates are the center of our current efforts.
Diazaborines are a Versatile Platform to Develop ROS Responsive Antibody Drug Conjugates
Angew. Chem. Int. Ed. 2021 (online)
Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional
Angew. Chem. Int. Ed. 2021, 60, 10850
Modular Assembly of Reversible Multivalent Targeting Drug Conjugates
Angew. Chem. Int. Ed. 2017, 56, 9346 –9350
Iminoboronates are Efficient Intermediates for Selective, Rapid and Reversible N-Terminal Cysteine Functionalisation
Chem. Sci. 2016, 7, 5052
Iminoboronates: A New Strategy for Reversible Protein Modification
J. Am. Chem. Soc. 2012, 134, 10299