Project Description

Wellcome- MRC Cambridge Stem Cell Institute, Cambridge, UK

José received his first degree in Biology from the University of Porto, in Portugal. He joined the GABBA graduate program from University of Porto and then went on to do his PhD studies at Imperial College under the supervision of Professor Neil Brockdorff on heritable silencing mechanisms during mouse development. In 2003 and following his PhD, José moved to Professor Austin Smith’s laboratory at the University of Edinburgh as an EMBO post-doctoral fellow to investigate factors involved in nuclear reprogramming. This work has led to the identification of Nanog as the first defined gene with nuclear reprogramming capacity in the conversion of a somatic cell into pluripotency. In 2008 José started his own lab at the Cambridge Stem Cell Institute investigating mechanisms of nuclear reprogramming. Currently, José is a Wellcome-Trust Senior Research Fellow. His work has defined roles and mechanisms by which the key drivers of nuclear reprograming work. He is also applying this acquired knowledge into other biological contexts such as X-chromosome-inactivation and stem cell potency.

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